Win 10 re-install stuck at REGION screen mouse + keyboard no response

Megahertz said:

What do you mean by "During a Win 10 re-install"?
- Is it a Clean install when you boot from a Win 10 USB installation drive?
Clean Install Windows 10
- Is it a Repair install when you run Setup from a Win 10 USB installation files?
Repair Install Windows 10 with an In-place Upgrade
- A Win 10 Reset?
Reset Windows 10

New Born Baby said:

Resetting the PC.
Not using a disk.
Proprietary apps started to fail (calculator, photos wouldn't open), then my PC wouldn't get past the login screen.
Ended up doing a reset.
Tried all USB ports makes no difference.

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Ending up doing a reset or a clean install?

You should have been using disk imaging - and you should check your disk.

I.e. what's the source of corruption that led to this.

Check disk (as I said above)
Clean install (see tutorial).

Good luck.

I agree with Dalchina. Everything points to a drive failure.

Boot from a Win 10 installation drive and at the Windows Setup screen, press Shift+F10 simultaneously to open a command line prompt. Type:
diskpart
list vol (take note of the Windows partition letter. It may not be C:)
exit
chkdsk X: /f (replace X with the letter found with list vol. Pay attention on the results)

The main drive is a HDD or a SSD?