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#1
Just tell it to skip. It is keeping the folder settings in that file. Deleting it sets the folder at a default setting.
Get and install LockHunter
Right click on the file "What is locking this file?"
Follow the steps from there
It's very simple. Open a CMD prompt using "Run as administrator". Enter "del /a:s thumbs.db". If you have subfolders involved, you can do "del /s /a:s thumbs.db" to remove all of the thumbs.db in a folder structure. Then you can remove the folders themselves.
JohnD
Sounds like Thumb.db is corrupted (which might be why you want to delete it)
If you haven't already, try this
Thumbnail Cache - Clear and Reset in Windows 10 - Windows 10 Forums
If that fails try it in Safe Mode
Safe Mode - Start Windows 10 in - Windows 10 Forums
Good luck :)