Thunderbird Profile problems

Hi, this may help you access your profile folder which, if you haven't, you may wish to back up.
Profile folder - Thunderbird - MozillaZine Knowledge Base

I would suggest you check your disk. Try
Download Portable HD Tune 2.55
- and run this from a USB drive - just in case, try avoiding writing to your disk for now.

Use the Health and Error scan tabs.

Then if ok run
chckdsk c: /scan
from an admin command or Powershell prompt and report the result.

Check the program's version can be done like this should you wish

although this may not be particularly informative at this point.

Can you start Thunderbird in its safe mode?
1. Open the ’Run’ dialog (Windows Key + R or click ’Start’ —> ’Run’)

2. Enter the path to Thunderbird: e.g.
”C:\Program Files\Mozilla Thunderbird\thunderbird.exe” -safe-mode".

You can check the path by rt clicking the shortcut to Thunderbird.
From the Win 10 start menu first rt click the shortcut, open the location of the shortcuts, rt click the shortcut. properties, detalis. (Yes, it's messy, thanks MS).

Do you have problems running any other programs?

Do you have a disk image you can restore? Tenforums members tirelessly recommend the routine use of disk imaging (e.g. Macrium reflect -free/paid + large external storage for image files) so you can readily restore a corrupt Windows installation or partition without technical help and so get back to a previous good state).

Another case of a self-repairing PC...