Win10 drops screen saver (I think) - besides it's an antiquated notion if you turn off display after ... minutes of inactivity.
Hibernate and Fast start are pretty much the same and are not needed, IMO.
Disable Hibernate (Admin command > powercfg /h -off)
Fast boot: UEFI only ... your choice, but might change booting from a Thumb drive. On, you might have to boot to the Thumb drive from within Windows.
USB Drive - Boot from in Windows 10 - Windows 10 Forums
Secure boot: I would leave this on as it adds one more security level. Navy points out the cons if you test other OSes.
Other things I disable, uninstall, turn off.
Most UWP Apps get uninstalled (cCleaner does this easily or you can use PowerShell)
Apps - Uninstall in Windows 10 - Windows 10 Forums
All Privacy options are enabled (or disabled depending on how the option is worded)
The Ultimate Windows 10 Security and Privacy Guide
I disable WER (rarely found any help from this) and Windows Experience (that disables most telemetry)
Windows Error Reporting
Control Panel\All Control Panel Items\Action Center
Control Panel\All Control Panel Items\Action Center\Change Action Center settings
Scroll down to the text links
Any CEIP has ties back to MS telemetry
How to Opt Out of the Microsoft Office Customer Experience Improvement Program
I do not let programs to continue running in the background (Chrome) and some UWP Apps.
I turn off access to almost everything (microphone, camera, sensors, location, maps, contacts, radios) - most of these settings are for the UWP Apps, which as you already know, I uninstall. If you use or try UWP Apps, these settings affect those Apps (mail needs contacts and mail, calendar needs contacts, maps, needs maps ... ) you get the idea
You might want to leave these alone until you're more familiar with Win10 or you're done playing
with UWP Apps. I think most will alert you if they need access and it's not on.
I do not display anything (that I can control) on my lock screen
I'm sure there is more.