I sure would like to see a log then. The "in use" message should usually come before Rufus attempts to write anything to the drive, so I'm puzzled your drive would disappear altogether. Or maybe you were using one of these weird Lexar JumpDrive Secure devices (see below).
Also, please be mindful that there are a bunch of applications (e.g. Defraggler, Genie backup Pro, etc.) that take a lock to an USB drive and never relinquish it, which they shouldn't do. See the list
here.
This means that the only applications that are going to be able to format such drives are the ones that don't request an exclusive lock. This is the precise reason I said the isotousb people might have deliberately chosen not to request an exclusive log, as there are quite a few applications that can be problematic if you do.
Okay, then your issue has nothing to do with 10547, in which case you're kind of hijacking a thread that's specific to 10547 for something unrelated.
Aside from using applications that can lock the drive (using Windows 10547 is not the only way you can find your drive locked), there are also other factors, such as using USB drives with encryption, such as some Lexar Jump Drives. These drives prevent low level access without jumping through hoops, and I could certainly scenarios where the drive would disappear if you try to repartition it. Also, have you tried listing all drives from Rufus' advanced mode? Or have you tried to see what the USB Debug mode of Rufus said about the detection process (Alt-.)? There are just two things that I could have advised you to perform, to try to figure out your issue, if you had just reported it.
You want to put part of the blame on Rufus? Sure. But please don't be surprised if, without any access to your logs, hardware or software data, I shift back the blame on to your environment, especially when you seem to be the only one reporting such a problem in millions of downloads, and you didn't take any steps to report it. I know this may sound harsh, but if you don't give the developer of an application
any chance to look into a problem you're having, you may want to refrain from pointing the finger at their app.