A misunderstanding, I see. Windows To Go is really usefol tool, I have a Kingston 128 GB Windows To Go Flash drive always in my pocket. What I meant was that relocating the Users folder in Windows To Go is pointless.
Yes, exactly That's why the whole operating system, all system files and folders must be on that computer, on the Windows To Go stick. Exactly as I tried to explain to you.
Yes it matters. You can not network PC1 and PC 2 and then relocate a system folder of PC1 to PC2, not even if the PC2 was always on and online when PC1 was booted.
Removable drive can be used for system folders as long as it has been formatted as NTFS. A FAT drive cannot be used.
However, your scenario will never work and there is no workaround. Windows To Go Flash drive is its own individual computer. All system files and folders must reside within that computer.
For me it's the same if you accept my answer or not. Apparently not as I told this already in my previous response to your post.
A system folder of a Windows installation cannot reside on another machine. End of story. A Windows installation, be it a clean install on a desktop or a laptop, or a Windows To Go drive must always have all necessary system folders available on that same machine. As far as Windows is concerned, the Windows To Go stick is an individual, independent Windows machine.
Your hopes and reality do not correlate regarding this matter.