How do you want to open this file? - Every time

mrgeek said:

"Why not just reinstall Office since that seems to be the problem."
You could try the faster "Repair" process too.

Did both- no change.

dalchina said:

What happens if you click the link in this? (attached)
- and make sure you reverse the registry change made previously..

As expected, it opens the web page in my default browser.

dalchina said:

And if you have a link to a file type other than jpg?

And what do you have here?

Looks the same:
{25336920-03F9-11cf-8FD0-00AA00686F13}

UPDATE- This problem is not limited to Excel, so it's possibly back to Windows 10 as the problem
I received some emails containing image files, and clicking on any of them normally would open the file with the Windows default program, but like Excel, I keep getting the "how do you want to open this file?" every time.

Fafhrd said:

I get a feeling of déjà vu when I see this thread:
keeps popping up despite default! - Windows 10 Forums
perhaps there are insights there?

Thanks, I did look there when you suggested it earlier. The only thing I haven't tried is to create a new user/profile.