Win10 App freezes outside of user folder

I have some apps that freeze/crash outside of my user folder. My biggest concern is a retro gaming platform called RetroArch. I can play old games online only if I move the program's folder to my user folder [Desktop]. But when I put it into the program files directory where all my games are carefully organized it just freezes when I try to join someone online to play (forcing me to open the task manager and close it that way).

I've tried all kinds of security settings for the whole folder, but even when give my login user, the user "SYSTEM", or the user "Everyone" "Full Control" it doesn't make a difference! I've also tried different ownership settings but nothing! I'm not a true expert and could really use your advise. Maby I overlooked an obvious setting or there's some other configuration options I'm unaware of.

But I never post to ask for help, so you can understand I've been searching and pulling my hair out over this problem for a while.

Anybody have any ideas? Right now I've changed ownership to "Everyone", removed all permissions except "Everyone" (which I've given full control to), disinherited permissions to all of the directory except for "Everyone" with "Full Control", copied all the files into the same directory, and checked to make sure there was an exception in the firewall but I still haven't solved the problem! There has to be some stupid hidden security feature I need to change (perhaps in the registry). Any help would be greatly appreciated.