I'm running Windows 10 Pro, Version 21H1, OS Build 19043.1052.

I've used the graphics manipulation program 'HyperSnap' for years with no problems at all. Recently a new version came out, so I did the update. Suddenly I couldn't save any of the image files created or modified in HyperSnap. In the case of a Save, the program simply closed; a Save-as would bring up a screen notification that the "File cannot be found...", which doesn't make sense, since I would have been creating a file within the target folder.

At this point I uninstalled HyperSnap and re-installed the older version. Oops, same problem exactly now. Can't save. However, I can save to the Windows Desktop just fine, and from there I can transfer the image file back into the proper folder where it belongs. So at least I'm back in business, just have to add a step in the file-saving process.

No other program on this computer has this problem at all. I can Save or Save-as into any folder from Word, Paint, or any other software I have installed. What's more, another Win10 machine running the same version of 10 works just fine with the HyperSnap program. So it's something on this machine, but only with this software program.

I don't know if this is a 'permissions' problem, or why the Desktop as a file destination would look to HyperSnap as different from any other folder under C:. But I'd sure like to get to the bottom of this. Many thanks in advance for any ideas.

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This situation was the result of Microsoft's Windows Defender not recognizing the HyperSnap app as a legit program. I actually found another post, from a guy who had the opposite problem, he couldn't save to the Desktop. Here's the link:
Please Wait... | Cloudflare
All it took was to go into Windows Defender and its Controlled Folder Access, and add the HyperSnap app to the whitelist of vetted programs. MS actually makes this easy by telling you what programs have recently been refused folder access. So a single click adds that program to the allowed list. Not sure why the original installation of HyperSnap was allowed for several years, but evidently the process of updating to the latest version raised a flag. Anyhow, one click and I'm back in business.