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#11
Over the years NTFS has shown itself to be quite resistant to fragmentation. Not resistant to being fragmented but to the consequences of fragmentation. It doesn't cause a real problem unless it reaches very high levels which is quite rare. I haven't used anything more than Windows built in defrag utility for a long time. Set the schedule and forget about it.
Edit: One thing you want to avoid is using multiple defrag utilities. Different utilities have different concepts of what optimum defrag results are so the last utility you use will waste much time undoing the actions of the one that ran before.