I googled the error code that was displayed by Macrium , as displayed in a screen shot previously in this thread, eventually finding this solution from an Acronis site.

Go to Start -> Run ->...

I found on another forum the solution to this.
[RESOLVED] VSS error 12292 with BR 11.5 for Windows Server | Acronis Forum
[I] deleted 1 line in the registry and now I can do a Macrium image backup....

Tune scan was fine and chkdsk results attached. I don’t think this is a hardware problem.
BTW this Surface Book 1 only has 1 disk with a c drive plus whatever boot partition they use.

Have finally got the machine up and running sweetly with all the apps loaded.
Thank you for all the help. I have been through your recommendations list
Now I am now trying to do a system backup....

Also in post 9 Samuria said to "remove all disallowed from the registry all document in frst.txt"
Not sure what is meant or how to do it.
Have completed AV scanning off line and run scannow and...

Well Defender is always on, so what other AV product do you recommend to run manually?

Then ... Is it just those 2 you recommend to run - chkdsk /x /f /r and HD Tune full error scan?
Have just...

Afraid I just couldn't go through all that again, so have reinstalled Windows while keeping my data.
Is there anything I should do now, whilst I reinstall all the apps?

these are the txt files produces

and this vbs has been produced

bitdefender uninstall download is corrupted and wont run. [B]ut see attachment

OK its gone now, what next

No not able to

Attached are the dxd and nfo files but none of the rest would run even with defender OFF.
Just popped up with "Unauthorised changes blocked"
Looks like a soft reinstall

Athough defender is turned off it still blocks anything from running

Microsoft Windows [Version 10.0.16299.125]
(c) 2017 Microsoft Corporation. All rights reserved.

C:\WINDOWS\system32>sfc /scannow

Beginning system scan. This process will take some time.
...

The beta was blocked as was the command line that I pasted.

C:\WINDOWS\system32>md "%USERPROFILE%\Desktop\CollectedFiles"&wmic /output:"%USERPROFILE%\Desktop\CollectedFiles\hotfix.txt" qfe list...

unable to do either the command option, even in safe mode, or the BSOD option, both saying "Access denied"

Guess I have to do the reinstall.
Are there still things to run after I have done a...

3 alternative paths suggested
Will do the BSOD first then try running the command text and finally will as a last resort, do the reinstall if all else has failed.
Will keep you updated and thanks...

Thank you both for your help.
I am in the wilds of the N Cornish coast with a weak intermittent internet service so I think I’ll wait till I’m somewhere with better access.
Wishing you happy days...

Any ideas. I’m reluctant to use this computer online in case it’s infected?

By turning off Defender I got it to work

Downloaded and ran the program but the creation and saving of the text file is blocked although I have allowed notepad.exe and FRST64.exe through Defender

Windows IP Configuration

Host Name . . . . . . . . . . . . : TheBook
Primary Dns Suffix . . . . . . . :
Node Type . . . . . . . . . . . . : Mixed
IP Routing Enabled. . . . . . . ....

MiniToolBox by Farbar Version: 17-06-2016
Ran by PC (administrator) on 22-12-2017 at 14:54:04
Running from "C:\Users\PC\Downloads"
Microsoft Windows 10 Pro (X64)
Model: Surface Book...

W10 Pro 64 bit on surface book
Fully updated.
I had a virus optimiser which I managed to get rid of, but still think I am infected.
When an attempt to install Malwarebytes or some other anti virus...