I have uninstalled the OPENVPN software and I am using the built in VPN solution from Windows 10 now.
Since 3 weeks I haven't seen this BSOD Message anymore.

It was indeed the OPENVPN Tab Driver.

Surface pro 4 Core M
BSOD IRQL_NOT_LESS_OR_EQUAL NTOSKRNL.EXE

Any ideas what is causing this ?

Thank you very much.
I did a fresh install and installed OPENVPN client seconds later..

Did another Fresh install this time without OPENVPN.
Let's see what happens.

You think this OPENVPN...

BSOD on Surface pro 4 Core M "Kernel_security_check_failure"
Tried many times clean installs etc. etc.

Could it be hardware ? (SSD)

I hope someone is able to analyze the minidump files.
...