I don't know if I want to share all that information. Could this be a non-paged pool memory leak from a driver? I see msrpc.sys (tag RpcM) using 500 megs in poolmon. I've tried out testing a leak...

That looks right.

https://support.hp.com/us-en/drivers/selfservice/hp-proone-600-g4-21.5-inch-non-touch-all-in-one-business-pc/21341226/model/21341245?sku=3DQ51AV

I have this weird problem with 2018 HP's (HP ProOne 600 G4 21.5-in Non-Touch AiO) in Windows 10 1809. Eventually, they can't launch any new applications, and any kind of remote script launch hangs...