And yes this problem didn't begin for me until the latest Windows 10 update ... on all of my PCs (3) and different Epson scanner models (3). Epson's 2013 software probably is due for a refresh, do ya...

I just tried a later suggestion and it worked great for me:
On my Dell PC, right clicked Epson scan shortcut and selected "Run as administrator" ...
A tiny pain to remember each time I'm selecting...