1. Turn System Restore OFF
2. - you've got the hidden volume shadow copy drives showing, (your pic), so there are probably quite a few of them (there are on mine), so just right-click each one and select Uninstall.
3. Close Device Manager and try to turn System Restore ON. See if you can create a restore point. If so, then try Macrium with a NEW test backup on Drive C, and see if it fails still.