Yes, sure. If that's your only available backup drive, then, yes, you'll want to delete the Windows images and turn that off.
When you first install/open Macrium, it will ask you if you want to make the rescue media. DO THAT! It's a very important step! Once it's created. make sure you can boot your system from it. To create the media at another time, select Other Tasks>Create Rescue Media.
Select the disk or partitions you want to image. In your case, you'd want to select the entire disk, all partitions.
Then select Image this disk.
Verify your selected disk/partitions.
Assign a folder on a separate drive for the backups.
Then click on Advanced Options.
Compression = Medium (Recommended)Then click Next.
Copy method = Intelligent Sector Copy
File Size = Automatic
Auto Verify Image: Yes, so check the box
Comments = information so you can identify what this archive is (i.e. W10 [computername] Full HDD Disk 0)
Here you can add a schedule. Perhaps you'd like this backup to be repeated weekly. Click Add Schedule to create your required schedule.
By default, Macrium will keep 12 full backups (and 4 differential backups, but you're not doing incrementals). Change that amount to whatever you like. I would keep at minimum 3, for redundancy. It's possible a backup could become corrupted, so you need more than one.
The Image Summary screen appears. Here you can verify everything you've set up, and make any changes if necessary.
Check the box to Run this backup now.
If you want to save this configuration to run in the future, click Save backup and schedules as XML Backup Definition File...
Enter a descriptive name for the Backup Definition file.
Click OK and the backup will begin.
You can use your computer while the backup is running.
If you scheduled backups, and your computer is not on when one is supposed to be run, it will run at next boot.
Be sure to check logs occasionally, for any problems.
That's it. It's quite easy, and very reliable.