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Check their website and make sure uit is compatible with Windows 10. If so go to services and disable Defender and the click on that drop down arrow on the top of your screen shot and click on don't notify me about this anymore or whatever is says. Good luck.
Already had a problem with the above , had error bdselfpt.sys and could not use the system at all . Uninstalled BD and went to Panda no signs of trouble since (full week) .
ESET :: Support :: Contact Customer Care
You could try to uninstall ESET and install it again or just contact the support.