How many NVMe drives can run on a motherboard while having SATA drives

I want to upgrade my pc as it is from 2015.
I currently have a Intel Core i5 4690K @ 3.50GHz and a Samsung ssd as my 'C' drive with two internal sata 7,200rpm drives plus a 4095MB NVIDIA GeForce GTX 1650 graphics card and 32.0GB Dual-Channel DDR3 @ 665MHz

Questions:
1) How many NVMe drives can run on a motherboard while having SATA drives plugged in? I see that 3 seems to be common.
I understand it has something to do with 'lanes' and if a SATA drive is plugged in then one of the NVMe ports will not work.

2) Is that still true for the latest motherboards?

3) Also should I be looking at boards with U.2 ports or just buy a card to plug in the future?

4) I would need a new ATX size case that will have these Thunderbolt & USB ports.
Any recommendations?

I am looking at this one. Any other recommendations would be welcome.
It has 3 x M.2 PCIe 4.0 x4 mode and 4 x SATA 3.0 ports
Also Thunderbolt Header + USB 3.2 Gen 1 header
USB 3.2 Gen 2x2 Type-C Connector

Intel® W680 (LGA 1700) ATX motherboard, PCIe® 5.0, DDR5, dual Intel® 2.5 Gb Ethernet, three PCIe 4.0 M.2 slots, USB 3.2 Gen 2x2 front panel connector, SlimSAS, SATA 6 Gbps, HDMI®, DisplayPort and VGA
Pro WS W680-ACE｜Motherboards｜ASUS USA

Amazon
Amazon.com: Pro WS W680-ACE Intel W680 LGA 1700 ATX Workstation Motherboard,2xPCIe 5.0x16 Slot,DDR5,ECC Memory,2x2.5 Gb LAN,3X M.2 Slots,USB 3.2 Gen 2x2 Front Panel,SlimSAS,BMC Header,Thunderbolt 4Header,ACCE. : Electronics

Can use up to a 13th Gen Intel i9 13900K cpu and max 128GB ram

If you look at the tech specs
Pro WS W680-ACE - Tech Specs｜Motherboards｜ASUS USA
read the manual before purchasing if you are not sure
Pro WS W680-ACE｜Motherboards｜ASUS USA

https://dlcdnets.asus.com/pub/ASUS/m...0WS%20W680-ACE

Thanks,
I looked at the 2 links and see how the drives are installed but I have not seen if I plug in a SATA drive, that will it disable one of the NVMe drives. Maybe that does not happen for the motherboard here.

Maybe the answer is here but I do not understand what I should be looking for.

Pro WS W680-ACE - Tech Specs｜Motherboards｜ASUS USA
Total supports 3 x M.2 slots and 8 x SATA 6Gb/s ports*
Intel® Core™ Processors (14th & 13th
& 12th Gen)

- M.2_1 slot (Key M), type 2242/2260/2280 (supports PCIe 4.0 x4 mode)
Intel® W680 Chipset**
- M.2_2 slot (Key M), type 2242/2260/2280 (supports PCIe 4.0 x4 mode)
- M.2_3 slot (Key M), type 2242/2260/2280/22110 (supports PCIe 4.0 x4 mode)
- 4 x SATA 6Gb/s ports
- 1 x SlimSAS Slot Support SlimSAS NVMe device (supports PCIe 4.0 x4 mode and up to 4 SATA devices)***
* Intel® Rapid Storage Technology supports PCIe RAID 0/1/5/10, SATA RAID 0/1/5/10.
** Intel® Rapid Storage Technology supports Intel® Optane Memory H Series on PCH attached M.2 slots.
*** SlimSAS slot can support up to 4 SATA devices via a transfer cable. the cable is purchased separately.

You can choose to use those four chipset lanes for SATA drives or a fourth Gen4 x4 NVMe drive

https://forum.level1techs.com/t/asus...0-ace/192319/3

Thanks SIW2. It looks then I can use 3 NVMe drives and plug in my 2 internal SATA drives without a conflict.

Looks like 3x nvme gen4 m.2 plus 4x sata3 ports

There is an option to use the slimsas for either an additional pcie gen4 or 4 additional sata ports.

Also a couple of pcie gen3 slots which could be used for nvme at gen3 speed with a cheap pcie >nvme adapter.

If I read that correctly populating one of the pcie 5 slots runs 16 lanes. If both are populated they both run 8 lanes.

I am now looking at the Asus ProArt Z790-CREATOR WIFI.
ProArt Z790-CREATOR WIFI - Tech Specs｜Motherboards｜ASUS USA

Total supports 4 x M.2 slots and 8 x SATA 6Gb/s ports*
Intel® Core™ Processors (14th & 13th & 12th Gen)
M.2_1 slot (Key M), type 2242/2260/2280/22110 (supports PCIe 4.0 x4 mode)
Intel® Z790 Chipset
M.2_2 slot (Key M), type 2242/2260/2280 (supports PCIe 4.0 x4 mode)
M.2_3 slot (Key M), type 2242/2260/2280/22110 (supports PCIe 4.0 x4 mode)
M.2_4 slot (Key M), type 2242/2260/2280 (supports PCIe 4.0 x4 & SATA modes)**
8 x SATA 6Gb/s ports**
* Intel® Rapid Storage Technology supports NVMe RAID 0/1/5, SATA RAID 0/1/5/10.
** M.2_4 slot shares bandwidth with SATA6G_5~8. SATA6G5~8 will be suspended once either a SATA or NVMe device is detected at M.2_4.

Thanks to all for helping.