NavyLCDR said:
Real world benchmark tests show that eSATA and USB 3.0 provide basically the same performance from hard drives connected to them. So, if you have a computer with only USB 2.0 and eSATA - the eSATA port is going to be many times faster than USB 2.0. If you have a computer with USB 3.0 and eSATA, you could expect about the same performance from either one - provided that whatever you connect to the USB 3.0 port is also a USB 3.0 device.
one other difference eSATA is bootable straight up.