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#11
Yes, Legacy or UEFI doesn't matter. I have two desktop PC's with legacy BIOS, they both have Digital Licenses for Home, Pro, Education and Enterprise. I can install any of those with a skip key and they will activate. Normally you would only have the one DL for any one PC. I do so much testing that I ended up with multiple DLs. I didn't plan it that way it just ended up like that.
The only big difference UEFI wise is embedded OEM keys. I don't think legacy has embedded keys. If your PC has an embedded Windows 10 key that will be read automatically by the install media and the matching version installed automatically. You won't be prompted to enter a key and version selection will be automatic. If its a Home key you get 10 Home, if its a Pro key you get Pro.