There are always potential negatives.
The best thing you can do as insurance against that is to FIRST make a complete disk image with a reliable imaging software. One example is Macrium Reflect Free. You should have a complete disk image stored on a completely separate external disk.
Before clean installing, you can save all of your device drivers by following the instructions in topgundcp's post here:
How do I backup all of my PC drivers 2 my flashdrive?
MS can do a decent job of installing appropriate drivers for your hardware in the clean install. You may need to follow-up by getting missing device drivers or more optimal drivers from Toshiba, or restoring the folder storing them from your disk image (or having them saved on separate media).
Note that any software you DO want to keep will have to be reinstalled and of course any data you want to keep will need restored - prepare all of that ahead of time.
Since your laptop came preinstalled with (and I assume was designed to run) Win10, you likely have much less chance of having driver difficulties or things going south on you than those who struggle to get much older laptops (with no manufacturer supplied Win10 drivers) upgraded.
Clean install can resolve a multitude of problems, especially if you've tweaked things in the wrong direction or otherwise lost some bits and pieces - and much can be said for getting rid of excessive bloatware.
I don't know how Toshiba is for bloatware but ONE THING you might consider is whether Toshiba provides a means of creating separate factory restore media for that laptop before you delete all partitions - there may be a partition there that contains the means to restore your laptop to the out-of-the-box state - some people consider that a valuable ultimate fallback to have -
From your laptop's user manual - http://support.toshiba.com/support/s...mTOCLink=false
A factory recovery USB separate from your computer is always a good thing to have early on (in my way of thinking) - I created and stored mine for my Dell in the factory box and store it in a separate safe and secure location. HOWEVER, that DOESN'T take away from the importance of just capturing a reliable complete disk image of where your laptop is NOW before embarking on the clean install.
Executive Summary (aka to some as the "TL;DR")- Create a factory recovery USB, Completely image your disk before starting, Create a separate easily accessible backup of your current drivers for convenience's sake.