No Boot, Drives Not detected, Can't Load Win10 Pleses Help!  

I recently put together a new PC, everything went fine and all was working great.
yesterday I booted the PC and I got a black screen telling me to "select a bootable drive" .
I was able to enter the bios and select my drive (M.2 NVME) (the boot order had changed for some reason) I was able to select the correct drive and boot normally.
But the boot order is getting changed each time I reboot.
I've tried to repair windows but it's telling me windows can't perform a repair.
I had set restore points, but windows doesn't show them.
I finally gave up and decided to reformat, but now my drive doesn't show up and windows keeps asking for a driver for the hard drive.
I now keeps booting directly to the bios, and NO sata or m.2_1 are listed as Present.
I changed the battery, resetting the bios to stock settings.
I flashed the bios to the newest firmware.
Boot mode is set to (Legacy + UEIF) I've tried changing that to just UEIF (No luck)
But nothing changes, Please any help here would be greatly appreciated!
Stuck and lost,

AMD Ryzen 5 2400G
MSI B450 Gaming Plus
Sabrent NVME PCIE M.2 2280 SSD
16 GB Corsair Vengeance plus LPX 2 2400 DDR4
Windows 10

Are you able to boot from a Windows 10 installation USB drive?

Yes I am able to boot to windows from a installation USB, but it won't locate sabrent M.2 drive.

One thing I forgot to mention, before this build went south I had installed a sumsung 250GB Nvme (For storage) into the PCIe slot using a RIITOP NVME Adapter.
That drive had windows 10 on it, but I immediately formatted it for storage and there we no problems at the time of installation.

OK.

There is a set of four "EZ Debug" LEDs, right next to the 24 pin ATX power connector. (P. 36 of the downloadable manual for the board.) Do any of those stay lit? (The LED for no boot device at least should be lit.)

Yes, 4th light down is only light lit, according to manual - (BOOT - indicates booting device is not detected or fail) and we are back at bios screen.

Sata port 1-4 not present, M2_1 not present.

Sorry it's taking a while to respond, I have a lot of irons in the fire right now but I really appreciate the help!

Do you have any drives connected to the SATA ports?

No, Nothing.

topgundcp said:

[*]If step one fails. Connect your 250GB SSD back in using one of the SATA port to see if the BIOS recognize it. .

How do you connect an NVMe SSD to a SATA port?

@MaggieDale,

Sounds like you have a bad SSD. I recently had 2 bad SSDs. One was ADATA, it would not be recognized at all. I can't remember what the second SSD was, but it was very intermittent, sometimes recognized, sometimes not. The third SSD, a Samsung, finally worked flawlessly. Since then I've bought two more SSDs, and they both test perfect in the same computer. So for me, it was definitely the first two SSDs that were bad, in a row, and not the motherboard.