Using SSD and HDD but Differing Partition Styles

The setup example is this: windows 10 on SSD (MBR Partition Style), Secondary HDD for Programs/Other-Stuff (GPT Partition-Style), I install programs onto the secondary drive (steam, VLC Media Player, etc...)

Will windows 10, at any point in the time I install updates or have to do repair installs for whatever reason, start having problems recognizing I got stuff installed on a GPT partitioned HDD, necessitating a need to convert the hard drive to an MBR partition table/style, or can I have the setup as an MBR/GPT or a GPT/MBR with no problems, or should I just stick with both storage drives being either MBR or GPT

It's fine to have both MBR and GPT disks. Normally, if you install Windows on a BIOS based system then the boot disk will be MBR because only UEFI based systems can boot from a GPT partition. However, other partitions can still be GPT.

Here is an article that does a good job explaining the differences:

What’s the Difference Between GPT and MBR When Partitioning a Drive?

Partitions are neither GPT nor MBR. Only physical drives are MBR or GPT. There is no issue mixing GPT and MBR drives in a system. But it is not possible to mix GPT and MBR partitions on a drive because MBR v. GPT does not apply to partitions.

then that is all I need, because at the time of this post I am now on an SSD/HDD setup, ssd holds the OS, HDD holds everything else, and the backup system I use is macrium reflect in cases of serious stuff

thanks everyone, this topic is now considered solved

@NavyLCDR is absolutely correct. In my post I initially referenced "MBR and GPT disks" but after that I referenced GPT partitions. I should have been clearer and said "partitions on GPT disks".

Sorry for the confusion and thanks for the correction, @NavyLCDR.