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If you use the ISO to perform an in-place upgrade of your existing system then your keep all your files and installed programs.
You don't actually need to burn the ISO to a DVD in order to perform an upgrade, you only need a DVD if you intend to boot from it to do a clean install (which would wipe out your installed Office).
To perform an in-place upgrade keeping your files and installed programs, first mount the ISO file by double-clicking on it. This will mount the ISO as a virtual DVD drive. Find Setup.exe on the root of the virtual DVD drive and run it to start the upgrade. The process of running an in-place upgrade is described starting at Step 4 this tutorial.
Repair Install Windows 10 with an In-place Upgrade | Tutorials