I have had no issues in using Sysprep in Build 10122, apart the fact that CopyProfile does not work and when set to true causes an endless reboot loop when booted to OOBE.
The /generalize switch is not needed if the only things the answer file does is to move the Users folder and / or add OEM information. Because /generalize is not needed, the PersistAllDeviceInstalls is also not needed and is completely unnecessary.
This is in all its simplicity the answer file I have now used in multiple installs on both physical and virtual installs to relocate the Users folder, it has worked without an issue every time:
Notice that you should install Windows without a network connection, connecting network only when booted to Audit Mode.
<?xml version="1.0" encoding="utf-8"?><unattend xmlns="urn:schemas-microsoft-com:unattend">
<component name="Microsoft-Windows-Shell-Setup" processorArchitecture="amd64" publicKeyToken="31bf3856ad364e35" language="neutral" versionScope="nonSxS" xmlns:wcm="http://schemas.microsoft.com/WMIConfig/2002/State" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<cpi:offlineImage cpi:source="wim:X:\Sources\install.wim#Windows 10 Pro Technical Preview" xmlns:cpi="urn:schemas-microsoft-com:cpi" />