As far as the system is concerned, Windows 10 seems happy to be up and running for weeks at a time. This wasn't the case (for me, at least) in Windows 7 where a restart was needed at regular intervals to reset 'oddities' that had crept into the system and/or drivers.

Mine's a laptop, so I hibernate it when the lid is shut and carry on from where I left off when I open the lid. It only get's a restart when updates need it to complete the install.