Why merging reg files works efficiently only from desktop?

I have reg file, which alter some restricted keys and it works only from desktop.
Like: [-HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Run]
I do not understand this, I am an admin, it does not work, whenever UAC is On or OFF.
I get a successful confirmation message from any location, but obviously it is lying to me.

How do you run them if not on the Desktop? They have to be run with elevated authority, like from an Elevated Command Prompt.

Perhaps right clicking and running as Administrator from elsewhere will work?

Ztruker said:

How do you run them if not on the Desktop?

I mean, they work only when run from the desktop folder. C:\Users\Name\Desktop\
Maybe creating a task with system rights might work, but I would prefer an easier way.

EDIT: OK, this strange problem was caused by explorer replacement Xyplorer.
When anything was run via it, it did work properly, via normal explorer it works.
I can not believe how much time I have wasted trying to figure it out. Odd anyway.

Glad you got an answer.