Windows on screen locked

Having an issue on one of my systems, and have no idea what the issue is.

I am running two monitors, already checked display drivers, and made sure the computer wasn't in tablet mode.

The issue I'm having is when the computer starts up, everything is fine, but after about 30 seconds of it being fully booted and ready for use, all the windows on the screen seem like they lock. You can minimize them, or maximize them, but cannot move them. I've looked through everything on the internet I can find, and even moved to a restore date from a month ago. Problem just started yesterday mid morning. It doesn't give any errors, just cannot move the screens. But I can drag and drop icons on the desktop, and click and make a selection there, but to highlight text for example in word isn't possible either. Really strange problem. Any ideas?

I'll try safe mode to see if it still does it. But no, they do not ever become unlocked. It's a very, very strange problem. I'll get back to you when I check in safe mode.

Safe mode everything worked fine like it should. What i'm finding is that everything works normally if I hold shift while clicking and moving a window around the screen. Same thing with highlighting.

I've re-installed drivers, and looked at everything I can see. But nothing about this screens moving with shift only.

Also holding CTRL makes it work as well. Same as highlighting text. I've made sure there aren't any sticky keys or anything funny going on as well.

No. There isn't anything special about it. There has to be a keystroke that she hit or something to cause this to be happening. I really do not want to rebuild the system unless I have to as it takes forever to get them back up and running with the software we have. This is like the other 30 systems we have in the building.

Like I said, I reinstalled the video drivers, and that did nothing, no windows utilities that I've tried have done anything, but if I hold CTRL, everything works just fine.

And when I say i reinstalled the video drivers, I deleted them, and installed the long way.

I'll try the clean boot and see where that gets me and report back. Thanks for the guidance so far.