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ESP usually stands for EFI System Partition, definitely you should not delete this. This partition should normally not have a drive letter associated with it. There have been other reports of it mysteriously gaining the letter 'F' in File Explorer but (curiously) not shown as having a drive letter in Drive Manager. If that is the case for you then...
http://superuser.com/questions/11130...-in-windows-10... restart the PC several times and it will disappear.
The hidden files get assigned a letter sometimes, if you try to mount any ISO via Explorer r-click. My 'mystery' drive letter is almost always 'Z'. You can simply remove the letter and the essential file will once again be hidden by:
Open command prompt (admin), type at each step, observing spaces-
diskpart (hit Enter)
list volume (hit Enter)
select volume # (corresponding to one you want to disassociate, in this case, 4 & hit Enter)
remove letter=F (Enter)
list volume (to double-check that this worked)
DONE