Can't click anything it happens often and randomly, after a lot of head banging I discovered killing Search.exe) using the keyboard) would solve the problem until it happened again.

The behavior is as if another window is taking focus or if you're clicking on something else.

I've tried formatting through Windows recovery and the problem persists. Disabling Windows Search fixes the problem but I really can't live without it.

Typical Intel Desktop with AMD GPU
Windows 10 Pro x64
Microsoft Wireless Mouse 5000

Nothing installed at this moment.

Also tried another mouse, the problem doesn't go away.

Appreciate any help troubleshooting this problem.