Google failed me this, people mentioned using setacl/subinacl, but no idea, how to use it.
Running typical commands as admin does not work for system folders/files. Like those:

takeown /f "C:\Program Files\Windows Defender" /a /r /d y
icacls "C:\Program Files\Windows Defender" /grant Mikai:f /t /c
icacls "C:\Program Files\Windows Defender" /setowner "Mikai" /t /c