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Windows 10 & 11 create tons of empty folders in System32
Windows 11 creates lots of empty folders in a System32 directory - gHacks Tech News
I found 2200 of them on my Windows 10 install, and 180 of them on my recent Windows 11 install.
C:\Windows\System32\config\systemprofile\AppData\Local
They're all empty folders, beginning with tw and ending with .tmp
Deleting them seems to have no side effects.