System no longer boots after msconfig Safe Mode setting

I am on Windows 10 Education and I was having difficulty entering Safe Mode. The system would not boot and I had to hit the power button to turn the system off and on again so it would start up normally. I decided to try going into Safe Mode with msconfig and now the system no longer boots period. I have tried disconnecting all SATA drives and still nothing. The fans and lights come on but the system never boots. Nothing appears on any monitor. I am faced now with an msconfig setting I need to change with no way to change it because the system no longer boots and I don't know how deep the issue goes to fix it. Do I need to replace the motherboard and hard drive? I have no idea.

Thank you for the response.

dalchina said:

There are no specs for your system. What is it and how old is it?

I have an MSI B450 Gaming Plus Max motherboard with an AMD Ryzen 5 1600 CPU, ASRock Radeon RX570 GPU, and G.Skills Ripjaws V RAM. It was assembled late last year.

dalchina said:

Do you see anything on the screen?

No.

Check the connection of the monitor to the graphics card. Also, if the motherboard itself has a video output, you may try plugging the monitor in to it.

NavyLCDR said:

Check the connection of the monitor to the graphics card. Also, if the motherboard itself has a video output, you may try plugging the monitor in to it.

Thanks for the suggestion. I've tried both but no change.

There should be a way to restore BIOS to defaults. Either a jumper that needs to be moved or a button to press. Try resetting the BIOS (clear CMOS settings).

I removed and replaced the battery and perhaps this is some kind of progress: I am getting a boot device error light. This is with both SSD and HD plugged in. Still nothing on the monitor, though.

PrettyDesperate said:

I removed and replaced the battery and perhaps this is some kind of progress: I am getting a boot device error light. This is with both SSD and HD plugged in. Still nothing on the monitor, though.

Does it do this with everything unplugged (only motherboard/memory/cpu/video/keyboard/mouse)? If yes it sounds like a failing motherboard. You can try without ram or video also, it should beep different codes each time.
beep codes

tomdsr said:

Does it do this with everything unplugged (only motherboard/memory/cpu/video/keyboard/mouse)

Yes. I don't understand why the board would be failing so quickly, though. I purchased it to replace an earlier board a month and a half ago. The only possible incident I can think that could have caused an issue with the board was an electrical issue with a USB port in the case(not the board itself) but that only seemed to cause a temporary issue with a device that was plugged into it. I have had no other issues until I attempted to use Safe Mode.