Yes, but there's a trade off between security and convenience so my suggestion is just to disable with only the PC having need to write to C:. Some modern programs such as Macrium Refflect, AOMEI Partition are still writing their log files to C:
Both Local group policy & Local security policy can be used to disable. However. these 2 policies are not available in Windows 10 Home.

So for Windows 10 Home users, they have to disable this option via the registry hack:
Windows Registry Editor Version 5.00