While I did reply directly to your post, the comment about refusing to troubleshoot wasn't directed at you personally, but directed at all who read it. In the future, if you've done troubleshooting, please post what troubleshooting you've done, as well as if you're seeing any errors in the event log (exactly what you did in the reply above).
Contacting ASUS for beta firmware is probably not going to garnish a result, as as soon as they release an updated version, if will be automatically updated on their drivers site for your model of device.
As far as your monitor goes, if the issue does come back after you've already adjusted settings within the BIOS, the most likely cause would be a drivers issue or a bad cable. If you took Nvidia's driver through Windows Update, download the most recent WHQL driver from Nvidia's site directly and update the driver with that setup package. If you have a different cable on hand, swap it out, however if you don't, don't immediately go out and buy one - verify first whether or not the drivers directly from Nvidia solved the issue.
Have you verified if any errors (yellow question marks) are showing up in device manager? While I mentioned it above in reference to nvidia, if a manufacturer offers drivers on their support site, it's always recommended to utilize those in lieu of the generic ones downloaded via Windows Update. In addition to being generic, Windows Update drivers will also generally not be the most recent drivers available.
As to the keyboard and mouse, is it a regular run of the mill keyboard, or does it have macro buttons, assignable or otherwise? If so, see if there's a driver's update from the manufacturer of the keyboard. If it is just a regular, run of the mill keyboard:
- Power down the system and unplug the main power cord (if a laptop, remove the battery as well), hold down the power button for 30 seconds, release, plug power cord back in, and turn the system on. If the problem still exists, proceed below.
- If this is a desktop, and the USB ports are on a pcie card, turn the system off, unplug the main power cable, hold the power button down for 30 seconds, open the case, unseat, then reseat the pcie card, close the case, plug power cord back in, and turn on the system. If the problem still exists, proceed below.
- Verify if the issue occurs if the keyboard and mouse are plugged into different USB ports (try the ones on your monitor)
- Hook a different device (preferably a keyboard or mouse, however any device should do) into the USB ports the mouse and keyboard are currently connected to, and see if the other device becomes non-responsive as well. The webcam would be a perfect way to do so, as you can simply turn it on and verify via the small preview window whether or not it freezes up. Make sure you leave it connected for 2x as long as it takes for the unresponsive issues to occur with the keyboard and mouse (this ensures you've left it connected long enough to replicate the issue)
While it would be out of the ordinary for both a keyboard and mouse to both fail at the time same time, if they were a package deal when you bought them, it would be a good idea to rule them out by connecting them to a different device to verify if the issue goes away (preferably another device running Win 10).