X99 USB Problems? What is it and how can i fix it? Code 43

So i am going to give a quick story of my problem.

When i first build this computer it had a Asus X99 Deluxe motherboard in with the 5820K CPU. All seems well till i started plugging in my USB drives. So i started getting a problem that it would just shut off my keyboard mouse and headset and just about all USB would go out till i rebooted. So i thought maybe i have a bad USB drive...Nope got a new WDC and had some problems as well so i then just replaced the motherboard with a GA-X99-Ultra Gaming thinking it was a bad motherboard. Replaced it and same problem is still there...now its getting bad to the point i can only have my Headset, Keyboard, Mouse if i plug in any "Drive" it just disables EVERYTHING! have to keep hard resting the computer.

I have tried just about everything i can think of other than replacing EVERYTHING in this computer.

I have some screen shots of what it looks like normal in device manger and then after i plug in a drive and what happens.

Normal Device Manger - https://goo.gl/photos/C42Gh2HxGnJZ1iz99

After Plugging in Driver - https://goo.gl/photos/SrvRxEtwEKr3LryE8

Error I get - https://goo.gl/photos/RiCwJDZAqkDgBW9H8

I even just re-installed my windows installed all drivers from Gigabytes website and most updated bios and still having problems. I am to the point i just wanted to sell all my parts and get a new system...any help would be great!!!!!!

**Note i have done some more testing and even called Intel thinking maybe it was my CPU and notice that it does not happen in safe mode only in normal windows...

TV2 said:

Can you list ALL the USB connected devices on this PC?
Would also be good to know the types of drives you are plugging in - Thumb drive, USB powered external drive, Self powered external drive.
Are you plugging these drives into the PC Case sockets, or the motherboard sockets on the back?
What are you running for a power supply?
When you replaced the motherboard, did you change the model or is it the same brand and model?

As of right now only things plugged in are Logitech keyboard, Logitech Mouse, Kingston Headset. Also included are my hx1000i power supply that is connect to a USB port on the motherboard to use the Corsair link and also my Corsair CPU cooler as well.

I have an external WDC 4TB drive that I would have plugged in the back but now I am unable to.

Seem that when I plug in a USB thumb drive any make or model or my external it shuts off all 3.0 ports. The 3.1 port does not shut off.

Does not matter if I plug it in from the case or in the motherboard itself.

TV2 said:

Yes. That is my first guess: That there could be a problem with the case USB ports, shorting out or under powered.
So the first thing I would try is to plug the "problem" drive(s) into the rear ports and see if the same thing happens.
The motherboard ports are powered differently, and use a different USB controller.

Yes I have already did that. Even disconnected that case USB from the motherboard to rule that out. When I plug them in the back they go out as well

As noted in the first post it's the GA-x99-ultra gaming

TV2 said:

Both times?

Both times what?