Cloning to M.2 NVMe via PCIe/M.2 expansion card. Hints?

I'm preparing to upsize my primary SATA SSD drive from 250GB to 500GB or 1TB. As they're priced about the same and my system is getting a few years on it figured I might, instead of continuing with SATA SSD, get a PCIe 4.0 M.2 NVMe drive which I can use in the next build (1 or 2 years from now).

My question is -- As my MB has no M.2 slots I'd be needing to use an expansion card in the available PCIe 3.0 x16 slot. I'd be doing the usual in-comp clone using Macrium or equivalent software. With just those two drives installed after the clone I'd shut down/uninstall the old primary/restart. I know I might have to enter UEFI to enable booting from that PCI slot. Might there be anything else I should be concerned about or looking for? Already have cloned backups on external drives and for ease I'll be sticking with MBR instead of performing a conversion.

I do have a clone taken immediately after the clean install which was done about four or five (maybe more ;-)) years ago. It doesn't have any of the changes since then but I'm almost ready to make that sacrifice just to get a renewed OS. Unfortunately I can't do a clean install off OEM disk as I'm running on a 10 upgrade which, if I understand correctly, is no longer an option.

Motherboard: ASUS P8Z77-V LK

You need a bios that supports nvme boot.

booting nvme disk via pcie adapter on older machines - Windows 7 Forums

you could check at win raid if somebody has already made one for your motherboard

Offers: Already modded special BIOSes - Win-Raid Forum

Thanks SIW2! Much appreciate the links and insight.

Amazingly I never ran across that info during my research of this upgrade. As it wouldn't have been a performance upgrade anyhow and simply a means of future proofing a single piece of hardware I believe I'll just stick with a SATA SSD.

Works perfectly on my 3rd gen system after the bios update.

Although I'm easily tempted and my search of the Win-Raid Forum did show one offer for my model board it feels like the obligatory "Use at your own risk", along with single success story, is enough to convince me the minimal reward of using an NVMe card cinches the SATA SSD choice. Still, I very much appreciate the education.