All USB devices suddenly stopped working upon startup a while ago

Windows 10 Home, version 1909, build 18363.836. 64-bit operating system, x64-based processor.

Namely can't access any thumb drives (nothing whatsoever happens when I plug them in) or use a USB mouse. Haven't tried with other USB devices. Non-USB headphones work fine. This started just today when I started up my computer, yesterday everything was working fine. Pretty sure this is not a physical issue, e.g. slots being obstructed or jammed somehow. Rebooted a few times to no effect.

if it helps, I did make some obscure setting changes recently that might've lead to this, while I was trying to fix an unrelated problem involving heavy disk use unreported by Task Manager over certain intervals:

• Through Registry Editor, set MSISupported from 1 to 0 in some folders in Computer\HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Enum\PCI\ . Didn't touch any other values. I'm not sure this is what caused it, I booted my computer up between changing those settings and today and USB mouse worked fine
• Through Services (services.msc) menu, disabled Connected Devices Platform User Service_5eafe and/or Connected Devices Platform Service. This was around the same time I was fiddling with Registry Editor, re-enabled that service once this issue showed up and rebooted but nothing happened.
• Disabled search indexing for C:\ (most of it, some folders being used by the system failed to have indexing turned off)
• Through Task Scheduler, disabled Microsoft\Windows\Application Experience\Microsoft Compatibility Appraiser (this ultimately fixed the heavy disk use issue I was talking about). This is the most recent change I made, however turning it back on would probably cause the heavy disk use to start up again.

Are there some common gotchas or other things I should check for? Thanks in advance.

Paul Black said:

Hello @Wisp,

Welcome to TenForums!

Firstly, have you tried a Restore Point prior to this happening?

Secondly, can you please perform the following . . .

[1] Goto this TenForums link => Batch Scripts / Programs.
[2] Goto the heading msinfo32 [ MS System Information ] - Find Problem Devices and download the .bat file.
[3] Run Option [2].
[4] Upload the results => How to Upload and Post Screenshots and Files at Ten Forums.

I hope this helps!

Thanks for the speedy reply!

I actually did try reverting to a restore point (last point was on May 11th), but it failed partway through because it couldn't restore a particular system folder, don't remember exactly what though.

msinfo32 responded in the negative (while my flash drive was plugged in, if it makes a difference):

The solution to this turned out to be quite mundane: after looking through Device Manager, I noticed the device "Intel(R) USB 3.0 eXtensible Host Controller - 1.0 (Microsoft)" said that there were too many other devices enabled for it to access the resources it needed, so I turned off two "Virtual Gamepad Emulation Bus" devices and tried updating its driver, and that did the trick.