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#11
Although it may be interesting to know which processes are accessing the disk, I guess your only comparison might be none. Comments have been mad about possible noise sources above.
Try booting to Safe Mode out of curiosity. Hopefully no activity then.
From the little shown, True Image and Snagit seem to show some activity- the relevant processes for D: are off the the bottom (lower pane).
Seems quite a bit may be happening- perhaps more than you want if the PC is meant to be idle.