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#31
I had the same issue -- Epson V500 scanner, Windows 10 x64. It worked fine up until around April 2018, when I started to see Epson Scan freeze while starting up, freeze in the middle of a scan, or "cannot communicate with scanner" errors. Reinstall/reboot didn't help.
What DID help was hasappra's solution posted earlier in this thread: i.e. changing C:\Windows\twain_32\escndv\escndv.exe to Windows XP SP3 compatibility mode for All Users. I've managed to scan 3 pages already, where I couldn't get through a single page before.
Thank you! Wish Microsoft and Epson support was as useful as this forum.