Recommended Security and Compatability Settings in IE11

I recently encountered a problem and had to re-set IE11. I now keep getting the message below so, the question is do I click "Use Recommended Settings" or do I click "Don't use Recommended Settings"? The point is that I have Norton Antivirus and I do not want this to clash with Defender.

Check Use Recommended...unless you want to modify IE security/compatibility settings.

Will not effect Norton/Defender.

Many thanks, it was the Norton/Defender link that concerned me.