In addition, :)
To get your machine back to a protected state, you can manually download and apply the latest Windows Defender definition update by following the instructions outline here:
Get the latest definitions - Microsoft Malware Protection Center
WIN DEFENDER Problem 
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New 04 Apr 2017 #11
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New 05 Apr 2017 #12
For those who have been experiencing the Windows Defender update error 0x80070643 recently, please check my latest update to the thread On Windows Defender Definition Update error 0x80070643.
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New 05 Apr 2017 #13
Many Thanks All
WD updates are back on track on this end
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