Pc taken over by viruses and malware

So my girlfriend got tricked by these multiple download button sites and unfortunately my pc is now possesed by all kinds of viruses and malware. It goes from hijacking my brownser (something called youndoo) to disabling the windows defender "permanently" ( had to go to the registry and delete some values).
I tried using adwcleaner. It did found something around 80 treats but didn't solve the problem.
So what should I do:
Scan my pc with windows defender or some other software;
Reset windows, but keep my files.
Reset windows and delete everything. Note that my w10 is installed in a ssd and everything else is on a hdd. Will it delete just the ssd stuff or everything on every drive?

Thanks in advance

Hmm I thought resetting would be the last resort. Thanks for the link, I will follow the guide and see if it works (tried some guides that didn't). And if it does work, how can I know that my pc is clean again? For instance, there is this Wizzcaster thing that opened random internet tabs that I disabled in the task mannager, but it is still here.

And while I typed that, windows defender found the a detplock trojan. I think I might cry

If you can do so our scans and post results PCHF System Scans

here are the logs

here are the logs

TairikuOkami said:

Resetting might not help, malware might have infected other drivers as well.

Remove the Youndoo.com Browser Hijacker (Uninstall Guide)

I successfuly removed youndoo from my pc thanks to this guide.I aprreciate that. The thing now is that windows defender is still finding some trojan when I scan my computer. In this case, is reseting the windows a valid option or not?

Cliff S said:

Try going into the settings app and run the Defender Offline scanner:
Windows Defender Offline Scan in Windows 10 - Windows 10 Tutorials

I don't have that option. And from what I see, your antimalware client version, antivirus and antispyware definitions are on a newer version than mine. Did I miss a windows update? I'm checking for updates now