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#11
The only thing I didn't do, pretty much, was enable Secure Boot. I don't know if TPM will actually work correctly, because even when this is a brand new Windows 10 21H2 installation, I installed Windows 10 with the Ryzen 7 3700X, flashed the BIOS to 2.10, then went to install the Ryzen 5 5600X. The AMI BIOS, prompted me to reset the TPM, because I changed the processor.
TPM is enabled by default with 2.10, according to ASRock, IIRC.