MB Premium and Antispyware

I'm running both of these and zero issues.

Does anyone run these AND a stand alone AV program?

I'm not sure what you mean by 'Antispyware'. Just be careful installing similiar security software as they can and often will conflict. And besides, installing more doesn't always mean better protection. You can make yourself more vulnerable if you aren't completely aware of what components are doing what, when and where. Just because some level of protection is enabled, perhaps running on several different software, doesn't mean it's going to work in the eventuality of a real and organized attack.

The belief that having more than one antivirus-like software installed is beneficial has no backing behind it. Because the truth is, one or ten makes little difference ultimately. The difference is what preventative measures have been taken prior to an attack which help mitigate downtime and/or cost in whatever context. If an attack happens, which is what you are protecting yourself from, it likely will happen and be successful regardless of what antivirus software you have. So how do you come back from having your computer hacked? What have you done prior to this to ensure you can get back up and running very quickly? An antivirus software won't ring work to tell them you can't come in because your online bank account has been emptied. An antivirus software won't restore your computer to a week in the past before the attack took place. It won't get the pictures of your family back if they somehow get deleted, damaged or otherwise. It may help with ransomware attacks but it can't bring back an entire collection of photos if they already have been messed with in some way. Antivirus doesn't help secure a network nor does it help secure a computer in terms of configuring it to be more restricted upon an attack taking place. Antivirus can't prevent your network getting hacked ie your router.

I would consider why you have what you have installed and what you think it does. And then assess based on this whether the protection offered is reflective of your requirements. Just installing software and then forgetting about it won't do much in the long run. The best solutions are the ones you can take on your own by understanding how best to protect your computer/network etc based on your individual needs. Malwarebytes and any other software will not be accountable should they fail to prevent an attack. But ultimately you may be if you could have done something to mitigate the risks.

Thanks for the detailed response.
I stated wrong. The programs I have are MB Premium, Superantispyware, and Windows Defender is enabled and all is working superbly together!

The programs you stated if running at once and all together is not recommended.

Doesn't matter. Until I see an issue, all is well.