Sorry, I don't know about any such registry changes but I am sure if you address this problem giving full details of the Game you are using and the 'Secure Rules' and 'Secure Profile' options that you have already tried, directly to alexandrud (who still maintains WFC under the umbrella of MalwareBytes), he may be able to help you as he has a long and active thread on wilderssecurity :

Windows Firewall Control (WFC) by | Wilders Security Forums

Good luck.