I'm not sure if this is a Chrome issue an Audio Sub-System or a Driver issue.

Background;
UNtil a couple of days ago I had an Nvidia GTX 960 that I connected to my HDTV with an HDMI cable. I ran the video and audio through the GTX 960, into the TV and out to my speaker system.

6 days ago on the 18th, I swapped my GTX 960 which was dying due to severe over-heating and age, for an RX580. The RX580 installed fine and everything appeared to go well. Video, Audio resumed as I had it before without the dying GTX 960's issues.

Approximately 2 days ago, I noticed an annoying issue;
I often open many Youtube tabs at once and then play, close, play down the list. Sometimes, as happens, I have to pause a video for anywhere from 30 seconds to a few hours before I can finish watching it. When I click to resume the video, the video plays but I have no sound until I refresh the page.

Until tonight, this issue was limited to Google Chrome. Tonight while watching a movie in VLC with some friends, I noticed that if I paused VLC, upon resume the audio will stay muted for 1-3 seconds, and then unlike Chrome, the audio will resume with no further issues unless I pause it again.

All nVidia Software/Drivers were uninstalled from the system before installing the new video card.

I am using Google Chrome v84.0.4147.135 (Official Build) (64-bit)
Radeon Software Version 2020.0515.1537.28108
Driver Version 19.50.29.27-200515a-355311C-RadeonSoftwareAdrenalin2020 (Which as far as I can tell is the most recent "recommended" version from AMD).

Windows 10 x64 Home, Version 1903 (OS Build 18362.1016)