This is a problem I've been having with Windows 10 since I upgraded from 7 and honestly it's making me want to reinstall 7 again.
Every so often, normally after only a few minutes, any windows applications that are open, including photos, the task manager or even the task bar, will not respond to the mouse. This means that it's not only not responding to clicking, but it won't react to having the cursor hovering over it. Trying to run commands in the command prompt will also be affected. Again, it seems like it's mostly just Windows applications as Chrome is not affected. Occasionally, Steam will be affected by this and will not respond similarly.
For some time I thought that this might have to do with my failing mouse's broken clickwheel as this was posing an issue on some of the games that I was playing on the device. I do have another mouse coming finally, which should help alleviate some of the issues (if not just make me a little bit happier).
The only workaround I've discovered so far is pressing ctrl+alt+del to be presented with the menu that can bring up task manager and then cancelling out of the menu. This will restore responsiveness normally 2/3 of the time. Bringing up the task manager itself does not resolve as ctrl+shift+esc does not help with this.
I have updated all my drivers to current but the issue is still occurring. Below is a screenshot of dxdiag for my system. Does anybody have any input on this?