Upgraded my VM and Laptop from 10159 to 10162. Both went perfectly, no problems. Took about an hour each.

The VM I did via Windows Update. Then as before, I used ESDtoISO to make the iso and copied it to my laptop.
Mounted the iso (right click, Mount) then ran setup.exe from the mounted ISO.
Upgrade took about as long as the upgrade via Windows Update.

On both, all programs still working and all data intact.

Nothing obviously new that I see so far.