How to "point" W10 install to a new drive (ssd)

My current C: drive, won't refresh because of "unsupported layout for UEFI firmware". Research indicates that I would have to clean off the entire disk (4 partions) in order to make it GPT so the install could proceed.
I have a 119GB SSD that I designated a GPT disk, but otherwise, it is empty. How would I direct a clean install of W10 to the SSD? If that works, how do I take the original boot drive out of operation while still retaining access to the many apps and programs on the original C: drive?

In your situation you should just use MBR instead of GPT, it might work a lot better. I am running my new Asus Z-97A with UEFI and MBR and it is a great combination.

That's what I'm doing at the moment, but when I try to do a refresh install, it fails with the message: "unsupported layout for UEFI firmware." Another big issue is that somehow I am missing a MSR partition on my boot drive.
Seems as though I'm going to have to clean the disk and reinstall.
Thanks for your support.

Here's a capture of my disk situation. Drive 4 is the boot drive. It seems to have no MSR partition. The entire disk is not GPT, and it seems that I can't install an MSR on a non-GPT disk. My present plan is to move the contents of F: to J: then convert F: to GPT and reinstall a backup of C: on F:
I have no idea if converting F: to GPT will automatically create a MSR partition; but I can try this without clearing Drive 4. I also have backups.
I am avoiding Drive E: (the SSD) because it is too small to hold my current Drive 4 C: partition. If I did put Win10 (only) on Drive E: , would other programs or apps also have to be placed on that drive, or could E: deal with them when they were on another drive? I am really unsure in this area because I have just been slapping new programs onto my rather large C: partition.
Thanks for your help.